ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibody
نویسندگان
چکیده
منابع مشابه
Antagonistic TNF Receptor One-Specific Antibody (ATROSAB): Receptor Binding and In Vitro Bioactivity
BACKGROUND Selective inhibition of TNFR1 signaling holds the potential to greatly reduce the pro-inflammatory activity of TNF, while leaving TNFR2 untouched, thus allowing for cell survival and tissue homeostasis. ATROSAB is a humanized antagonistic anti-TNFR1 antibody developed for the treatment of inflammatory diseases. METHODOLOGY/PRINCIPAL FINDINGS The epitope of ATROSAB resides in the N-...
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ژورنال
عنوان ژورنال: mAbs
سال: 2010
ISSN: 1942-0862,1942-0870
DOI: 10.4161/mabs.2.6.13583